NALTRINDOLE HYDROCHLORIDE
NALTRINDOLE HYDROCHLORIDE
CAS: 111469-81-9
Molecular Formula: C26H27ClN2O3
NALTRINDOLE HYDROCHLORIDE - Names and Identifiers
| Name | NALTRINDOLE HYDROCHLORIDE |
| Synonyms | NTI NaltrindoleHCl NTI HYDROCHLORIDE NALTRIDOLE HYDROCHLORIDE NALTRINDOLE HYDROCHLORIDE NALTRINDOLE HYDROCHLORIDE (NTI) NON-PEPT IDE DELTA OPI 17-(CYCLOPROPYLMETHYL)-6,7-DEHYDRO-4,5A-EPOXY-3,14-DIHYDROXY-6,7-2',3'-INDOLOMORPHINAN HYDROCHLORIDE 17-(Cyclopropylmethyl)-6,7-dehydro-4,5alpha-epoxy-3,14-dihydroxy-6,7-2',3'-indolomorphinan hydrochloride |
| CAS | 111469-81-9 |
NALTRINDOLE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C26H27ClN2O3 |
| Molar Mass | 450.96 |
| Solubility | methanol: 4.5mg/mL |
| Appearance | solid |
| Color | off-white |
| Storage Condition | −20°C |
| In vitro study | Opioid drugs exert a wide spectrum of physiological and behavioral effects. These effects are mediated via membrane-bound receptors, of which the best characterized are the kappa, delta, and mu receptors. Naltrindole inhibits the proliferation of cultured human U266 MM cells in a time- and dose-dependent manner with an EC 50 of 16 μM. Treatment of U266 cells with naltrindole significantly decreases the level of the active, phosphorylated form of the kinases, extracellular signal-regulated kinase and Akt, which may be related to its antiproliferative activity. Naltrindole inhibits growth and induces apoptosis in the three characteristic SCLC cell lines, NCI-H69, NCI-H345, and NCI-H510. Naltrindole treatment reduces constitutive phosphorylation of Akt/PKB on serine 473 and threonine 308 in cells and also its downstream effectors glycogen synthase kinase-3β and the Forkhead transcription factors AFX and FKHR. |
| In vivo study | Naltrindole significantly decreases tumor cell volumes in human MM cell xenografts in severe combined immunodeficient mice. In mice, naltrindole at 20 mg/kg s.c. antagonizes the δ-selective agonist effect of [D- Ser, Leu, Thr]enkephalin (DSLET) without blocking the antinociceptive effect of morphine or U50488H. Naltrindole is the only highly selective δ antagonist that is active upon peripheral administration. Acute naltrindole induces significant decreases in external and total ambulation (horizontal activity) and rearing behaviour (vertical activity), as well as a significant increase in grooming frequency. In animals chronically treated with naltrindole there is an increase in total ambulation one day after the discontinuation of the treatment. |
NALTRINDOLE HYDROCHLORIDE - Risk and Safety
| WGK Germany | 3 |
NALTRINDOLE HYDROCHLORIDE - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 2.218 ml | 11.088 ml | 22.175 ml |
| 5 mM | 0.444 ml | 2.218 ml | 4.435 ml |
| 10 mM | 0.222 ml | 1.109 ml | 2.218 ml |
| 5 mM | 0.044 ml | 0.222 ml | 0.444 ml |
Last Update：2024-01-02 23:10:35
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CAS: 111469-81-9
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CAS: 111469-81-9
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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